Comprehensive Landscape of Cyclin Pathway Gene Alterations and Co-occurrence with FGF/FGFR Aberrations Across Urinary Tract Tumors.

Denis Leonardo Fontes JardimSherri Z MillisJeffrey S RossScott LippmanSiraj M AliRazelle Kurzrock

Published in: The oncologist (2022)

Cyclin pathway activating alterations are common in urinary tract tumors, but frequency varies with histology and tumors sites. Co-occurrence of cyclin and FGFR pathway alterations may inform therapeutic opportunities.

Keyphrases

urinary tract
cell cycle
copy number
cell cycle arrest
gene expression
single cell
genome wide
cell death
dna methylation
pi k akt