Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes.
Travis NemkovDaniel StephensonEric J EarleyGregory R KeeleAriel HayAlicia KeyZachary HaimanChristopher EricksonMonika DzieciatkowskaJulie A ReiszAmy MooreMars StoneXutao DengSteven KleinmanSteven L SpitalnikEldad A HodKrystalyn E HudsonKirk C HansenBernhard O PalssonGary A ChurchillNareg RoubinianPhilip J NorrisMichael P BuschJames C ZimringGrier P PageAngelo D'AlessandroPublished in: bioRxiv : the preprint server for biology (2024)
Blood donor age and sex affect glycolysis in stored RBCs from 13,029 volunteers;Ancestry, genetic polymorphisms in PFKP, HK1, CD38/BST1 influence RBC glycolysis;Modeled PFKP effects relate to preventing loss of the total AXP pool in stored RBCs;ATP and hypoxanthine are biomarkers of hemolysis in vitro and in vivo.