GCSB-5 regulates inflammatory arthritis and pain by modulating the mitogen-activated protein kinase signaling pathway in a murine model of rheumatoid arthritis.

Jihye Bang Gyeong Hwa Kim Soo-Young Park Hae Ra Jung Sang-Hyon Kim Ji-Min Kim

Published in: Archives of rheumatology (2022)

GCSB-5 decreased inflammatory arthritis and pain in a murine model of RA. The results present evidence that GCSB-5 may be beneficial for relieving pain as well as decreasing inflammation in autoimmune arthritis, such as RA.

Keyphrases

rheumatoid arthritis
chronic pain
disease activity
signaling pathway
pain management
oxidative stress
neuropathic pain
ankylosing spondylitis
multiple sclerosis
epithelial mesenchymal transition
spinal cord injury
cell proliferation
protein kinase