The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report.
Kate L HarknessTrisha ChakrabartySakina J RizviRaegan MazurkaLena QuiltyRudolf UherRoumen V MilevBenicio N FreySagar V ParikhJane A FosterSusan RotzingerSidney H KennedyRaymond W LamPublished in: Canadian journal of psychiatry. Revue canadienne de psychiatrie (2023)
We identify emotional maltreatment as a specific early exposure that places patients at the greatest risk for nonremission following pharmacological treatment. Further, we suggest that anhedonia is a key symptom domain driving nonremission in patients with particular maltreatment histories.