Contributions of amyloid beta and cerebral small vessel disease in clinical decline.
Justine E F MoonenRenée HaanIsabelle BosCharlotte TeunissenElsmarieke van de GiessenJori TomassenAnouk den BraberSophie M van der LandenEco J C de GeusNienke LegdeurArgonde C van HartenCalvin TrieuCasper de BoerLior KroezeFrederik BarkhofPieter Jelle VisserWiesje M van der FlierPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Amyloid beta (Aβ; A) was predictive for cognitive decline, dementia, and mortality. Small vessel disease (SVD) had no additional deleterious effects in A+. SVD modestly predicted dementia in A-. Aβ should be assessed even when magnetic resonance imaging indicates vascular cognitive impairment.