Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages.
Martin A BewleyJulie A PrestonMohammed MohasinHelen M MarriottRichard C BuddJulie SwalesPaul ColliniDavid R GreavesRuth W CraigChristopher E BrightlingLouise E DonnellyPeter J BarnesDave SinghSteven D ShapiroMoira K B WhyteDavid H DockrellPublished in: American journal of respiratory and critical care medicine (2017)
Up-regulation of Mcl-1 and chronic adaption to oxidative stress alter mitochondrial metabolism and microbicidal function, reducing the delayed phase of intracellular bacterial clearance in COPD.