GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.
Bjørn Odvar EriksenRunolfur PalssonNatalie EbertToralf MelsomMarkus van der GietVilmundur G GudnasonOlafur Skuli IndridasonLesley A InkerTrond G JenssenAndrew S LeveyMarit D SolbuHocine TighiouartElke SchaeffnerPublished in: Journal of the American Society of Nephrology : JASN (2020)
Healthy aging is associated with a higher mean GFR compared with unhealthy aging. However, both the mean and 97.5 percentiles of the GFR distribution are lower in older persons who are healthy than in middle-aged persons who are healthy. This suggests that healthy aging is not associated with preserved GFR in old age.