Mesenchymal stem cells promote ovarian reconstruction in mice.
Jiazhao LiHaonan FanWei LiuJing ZhangYue XiaoYue PengWeijie YangWenwen LiuYuanlin HeLianju QinXiang MaJing LiPublished in: Stem cell research & therapy (2024)
The presence of BM-MSCs in the artificial ovary was found to promote the survival of ovarian cells, as well as facilitate follicle formation and development. Since the cells didn't proliferate in the reconstituted ovary, this discovery suggests a potential new and safe method for the application of MSCs in clinical fertility preservation by enhancing the success rate of cryo-thawed ovarian tissues after transplantation.
Keyphrases
- mesenchymal stem cells
- induced apoptosis
- umbilical cord
- cell cycle arrest
- gene expression
- small molecule
- oxidative stress
- stem cells
- endoplasmic reticulum stress
- cell therapy
- bone marrow
- metabolic syndrome
- pregnant women
- risk assessment
- high throughput
- insulin resistance
- mass spectrometry
- climate change
- high fat diet induced