Feline leukocyte adhesion (CD18) deficiency caused by a deletion in the integrin β2 (ITGB2) gene.

Thomas R Bauer Suzanne M PrattChristina M PalenaKarthik RajUrs Giger

Published in: Veterinary clinical pathology (2017)

Feline LAD exhibits features similar to LAD in other species. However, clinical episodes in FLAD appeared milder allowing for an extended life expectancy under long-term antimicrobial therapy, possibly due to an alternative, CD18-independent T-cell proliferation pathway.

Keyphrases

cell proliferation
staphylococcus aureus
nk cells
genome wide
copy number
cell cycle
escherichia coli
peripheral blood
replacement therapy
pi k akt
dna methylation
transcription factor
cell therapy
genome wide analysis