Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Linda AnderssonMathieu CinatoIsmena MardaniAzra MiljanovicMuhammad ArifAra KohMalin LindbomMarion LaudetteEntela BollanoElmir OmerovicMartina KlevstigMarcus StahlmanPer FogelstrandKarl SwärdMatias EkstrandMax LevinJohannes WikströmStephen DoranTuulia HyötyläinenLisanna SinisaluMatej OresicÅsa TivestenMartin AdielsMartin O BergoRichard L ProiaAdil MardinogluAnders JeppssonJan BorénMalin C LevinPublished in: European heart journal (2021)
Our findings suggest that cardiac glycosphingolipids are required to maintain β-adrenergic signalling and contractile capacity in cardiomyocytes and to preserve normal heart function.