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Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.

Linda AnderssonMathieu CinatoIsmena MardaniAzra MiljanovicMuhammad ArifAra KohMalin LindbomMarion LaudetteEntela BollanoElmir OmerovicMartina KlevstigMarcus StahlmanPer FogelstrandKarl SwärdMatias EkstrandMax LevinJohannes WikströmStephen DoranTuulia HyötyläinenLisanna SinisaluMatej OresicÅsa TivestenMartin AdielsMartin O BergoRichard L ProiaAdil MardinogluAnders JeppssonJan BorénMalin C Levin
Published in: European heart journal (2021)
Our findings suggest that cardiac glycosphingolipids are required to maintain β-adrenergic signalling and contractile capacity in cardiomyocytes and to preserve normal heart function.
Keyphrases
  • heart failure
  • atrial fibrillation
  • skeletal muscle
  • left ventricular
  • replacement therapy
  • smooth muscle