PAR2 promotes impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and Akt interference.

Andrew M ShearerYanling WangElizabeth K FletcherRajashree RanaEmily S MichaelNga NguyenManal F AbdelmalekLidija CovicAthan Kuliopulos

Published in: Hepatology (Baltimore, Md.) (2022)

This work provides evidence that PAR2 is a major regulator of liver glucose homeostasis and a potential target for the treatment of diabetes and NASH.

Keyphrases

blood glucose
type diabetes
cardiovascular disease
signaling pathway
cell proliferation
combination therapy
adipose tissue
human health