Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations.

Arthur H TottenGulbu UzelPavel P KhilJung-Ho YounJennifer TreatCraig D Soutar Steven M Holland John P Dekker Christa S Zerbe

Published in: Open forum infectious diseases (2022)

Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 ( PI3KR1 ) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.

Keyphrases

protein kinase
end stage renal disease
ejection fraction
transcription factor
newly diagnosed
chronic kidney disease
cystic fibrosis
tyrosine kinase
peritoneal dialysis