MicroRNA-221-3p Targets THBS1 to Promote Wound Healing in Diabetes.

Keyan HuXueying LiuHongfeng ChangYi ZhangHui ZhouLei LiuXin ZhangZiying JiaoBing ShenQiu Zhang

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2023)

Our findings suggested miR-221-3p might exert an essential impact on diabetes WH via inhibition of THBS1 and lack of miR-221-3p possibly results in impaired healing in chronic wounds of type 2 diabetes. Therefore, developing medicine such as chemically modified analogs of miR-221-3p in future could benefit patients with DFU.

Keyphrases

wound healing
type diabetes
cardiovascular disease
glycemic control
current status
metabolic syndrome
insulin resistance