CPAP and EPAP elicit similar lung deflation in a non-equivalent mode in GOLD 3-4 COPD patients.
Paulo de Tarso MüllerGustavo ChristofolettiRodrigo KochJoão Henrique Zardetti NogueiraLuiz Armando Pereira PatuscoGaspar Rogério ChiappaPublished in: The clinical respiratory journal (2017)
Twenty-one eligible COPD patients were studied (13 male/8 female, FEV1 % predicted of 36.5 ± 9.8). Both CPAP and EPAP demonstrated significant post-pre (Δ) changes for IC and PImax, with mean ΔIC for CPAP and EPAP of 200 ± 100 mL and 170 ± 105 mL (P = .001 for both) in 13 and 12 patients (responders) respectively. There were similar changes in % predicted IC and PImax (∼7%, P = .001 for both) for responders and poor responder/non-responder agreement depending on CPAP/EPAP mode (Kappa = .113, P = .604). There were no differences in CPAP and EPAP regarding intensity of lung deflation (P =.254) and no difference was measured regarding HR (P = .235) or SpO2 (P = .111). CONCLUSIONS: Both CPAP and EPAP presented a similar effect on lung deflation, without guaranteeing that the response to one modality would be predictive of the response to the other.
Keyphrases
- end stage renal disease
- obstructive sleep apnea
- newly diagnosed
- ejection fraction
- chronic kidney disease
- sleep apnea
- peritoneal dialysis
- prognostic factors
- chronic obstructive pulmonary disease
- patient reported outcomes
- inflammatory response
- lung function
- air pollution
- toll like receptor
- patient reported
- nuclear factor
- silver nanoparticles