Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.

Nady GolestanehYi ChuShuk Kei ChengHong CaoEugenia PoliakovDaniel M Berinstein

Published in: Journal of translational medicine (2016)

Our studies suggest SIRT1/PGC-1α as underlying pathways contributing to AMD pathophysiology, and open new avenues for development of targeted drugs for treatment of this devastating neurodegenerative disease of the visual system.

Keyphrases

age related macular degeneration
oxidative stress
skeletal muscle
ischemia reperfusion injury
cancer therapy
replacement therapy