Super-resolution Microscopy for Nanomedicine Research.
Silvia PujalsLorenzo AlbertazziPublished in: ACS nano (2019)
Super-resolution microscopy, or nanoscopy, revolutionized the field of cell biology, enabling researchers to visualize cellular structures with nanometric resolution, single-molecule sensitivity, and in multiple colors. However, the impact of these techniques goes beyond biology as the fields of nanotechnology and nanomedicine can greatly benefit from them, as well. Nanoscopy can visualize nanostructures in vitro and in cells and can contribute to the characterization of their structures and nano-bio interactions. In this Perspective, we discuss the potential of super-resolution imaging for nanomedicine research, its technical challenges, and the future developments we envision for this technology.
Keyphrases
- single molecule
- high resolution
- cancer therapy
- induced apoptosis
- atomic force microscopy
- living cells
- single cell
- cell cycle arrest
- cell therapy
- endoplasmic reticulum stress
- signaling pathway
- current status
- human health
- drug delivery
- mesenchymal stem cells
- oxidative stress
- stem cells
- bone marrow
- pi k akt
- risk assessment
- optical coherence tomography
- high throughput
- high speed