Sensitive subcellular scale and real-time detection of hydrogen peroxide by a W-doped Pt microelectrode.
Shaohui LeiZhuo ZouKangling TianYan ZhengMei DingGuangxuan HuHong Bin YangChun Xian GuoChangming LiFang Xin HuPublished in: Chemical communications (Cambridge, England) (2024)
A W-doped Pt modified graphene oxide (Pt-W-GO) electrochemical microelectrode was developed to detect hydrogen peroxide (H 2 O 2 ) in real time at a subcellular scale. Interestingly, results showed that the concentration of H 2 O 2 in the nucleus of HeLa cells was 2.68 times and 0.51 times that in the extracellular membrane and cytoplasm, respectively.
Keyphrases
- hydrogen peroxide
- quantum dots
- cell cycle arrest
- nitric oxide
- deep brain stimulation
- induced apoptosis
- label free
- highly efficient
- gold nanoparticles
- cell death
- visible light
- ionic liquid
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- loop mediated isothermal amplification
- simultaneous determination