Alteration of myoepithelial cells during botulinum toxin type A-inhibited salivary secretion.

Hui XuHuabing GeXiao-Feng Shan Zhi-Gang Cai

Published in: Oral diseases (2023)

BoNT/A temporarily caused MEC atrophy and decreased MEC contractility in rat SMGs, which contributed to reversible inhibition of salivary secretion. The underlying mechanisms involved temporary parasympathetic denervation caused by SNAP-25 cleavage. These findings provide new insights into the mechanisms of BoNT/A-inhibited salivary secretion.

Keyphrases

botulinum toxin
induced apoptosis
oxidative stress
heart rate variability
cell cycle arrest
smooth muscle
signaling pathway
pi k akt