Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome.

Shirelle X LiuTenille K FredricksonNatalia Calixto MancipeMichael K GeorgieffPhu V Tran

Published in: Nutrients (2023)

This study provided unbiased global assessments of gene expression regulated by iron and choline in a sex-specific manner, with greater effects in female than male rats. Our new findings highlight potential sex-specific gene networks regulated by iron and choline for further investigation.

Keyphrases

iron deficiency
early life
gene expression
genome wide
dna methylation
pregnant women
oxidative stress
rna seq
single cell
replacement therapy
brain injury
transcription factor
cerebral ischemia