A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking.

Nourhan ShalabyJohn KellyFrancisco MartinezMathew FoxQi QiJonathan ThiessenJustin HicksTimothy J SchollJohn A Ronald

Published in: Molecular imaging and biology (2022)

Our study demonstrates the ability to noninvasively track cells engineered with our human-derived dual MRI/PET reporter system, enabling a more comprehensive evaluation of transplanted cells. Future work is focused on applying this tool to track therapeutic cells, which may one day enable the broader application of cell tracking within the healthcare system.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
magnetic resonance imaging
computed tomography
single cell
gene expression
stem cells
positron emission tomography
pet ct
signaling pathway
dna methylation
mesenchymal stem cells
diffusion weighted imaging
current status
genome wide analysis