Cocaine, amphetamine, or titin: Unraveling the genetic underpinnings of dilated cardiomyopathy.
Binay Kumar PanjiyarNikita ChanglaniClarisa MedinaLisa R TrevinoPublished in: Clinical case reports (2024)
This case report examines a 33-year-old Hispanic male with bipolar disorder, schizophrenia, and a history of substance use, presenting with acute respiratory failure and cardiac arrest. The patient's nonischemic dilated cardiomyopathy (DCM) highlights the critical role of genetic factors, particularly titin gene (TTN) mutations, in cardiomyopathy pathogenesis. Through genetic analysis, we explore the intersection of lifestyle factors and genetic predisposition in DCM, underscoring the importance of comprehensive genetic testing for accurate diagnosis and targeted therapy. This case contributes to the evolving understanding of DCM etiology, emphasizing the necessity of considering both environmental and genetic factors in clinical assessment and management.
Keyphrases
- bipolar disorder
- respiratory failure
- case report
- genome wide
- copy number
- cardiac arrest
- major depressive disorder
- cardiovascular disease
- extracorporeal membrane oxygenation
- metabolic syndrome
- dna methylation
- heart failure
- mechanical ventilation
- cardiopulmonary resuscitation
- gene expression
- intensive care unit
- mass spectrometry
- cardiac resynchronization therapy
- aortic dissection