Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice.

Ying Linda LinMeir BialerRobert M CabreraRichard H FinnellBogdan J Wlodarczyk

Published in: Birth defects research (2018)

The study demonstrates that the teratogenicity of VPA was significantly greater than that of an equimolar dose of VCD. Four genes (Mtap2, Bmp8b, Stat3, and Heyl) represent candidate target genes for the underlying teratogenic mechanism responsible for VPA-induced malformations.

Keyphrases

genome wide
genome wide identification
bioinformatics analysis
high glucose
mesenchymal stem cells
cell proliferation
type diabetes
high fat diet induced
gene expression
dna methylation
drug induced
endothelial cells
bone marrow