HBx Protein Contributes to Liver Carcinogenesis by H3K4me3 Modification Through Stabilizing WD Repeat Domain 5 Protein.

Weiwu GaoZhengcai JiaYi TianPenghui YangHui SunChenhui WangYi DingMengjie ZhangYi ZhangDi YangZhiqiang TianJian ZhouZhihua RuanYuzhang WuBing Ni

Published in: Hepatology (Baltimore, Md.) (2020)

Our data reveals that WDR5 is a key epigenetic determinant of HBV-induced tumorigenesis and that the HBx-WDR5-H3K4me3 axis may be a potential therapeutic target in HBV-induced liver pathogenesis.

Keyphrases

hepatitis b virus
high glucose
diabetic rats
liver failure
dna methylation
gene expression
drug induced
protein protein
amino acid
endothelial cells
electronic health record
big data
machine learning
oxidative stress
binding protein
small molecule
data analysis