Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors.
Diogo E S NogueiraCarlos A V RodriguesMarta S CarvalhoCláudia C MirandaYas HashimuraSunghoon JungBrian LeeJoaquim M S CabralPublished in: Journal of biological engineering (2019)
The results here described present the Vertical-Wheel bioreactor as a promising technology for hiPSC bioprocessing. The specific characteristics of this bioreactor, namely in terms of the innovative agitation mechanism, can make it an important system in the development of hiPSC-derived products under current Good Manufacturing Practices.