Pharmacokinetics and pharmacodynamics of intravenous esomeprazole at 2 different dosages in dogs.

The pharmacokinetic parameters and acid suppressant effect for 0.5 and 1 mg/kg esomeprazole were not significantly different. Furthermore, the efficacy of esomeprazole 0.5 mg/kg IV q12h was sufficient to increase intragastric pH in Beagles.