Gene-environment analyses reveal novel genetic candidates with prenatal tobacco exposure in relation to risk for childhood acute lymphoblastic leukemia.

Charlie Zhong Shaobo Li Katti Arroyo Libby M Morimoto Adam J de Smith Catherine Metayer Xiaomei Ma Scott C Kogan W James Gauderman Joseph L Wiemels

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)

Despite lack of an overall "main effect," tobacco exposure during pregnancy impacts childhood ALL risk depending on specific genetic variants.

Keyphrases

acute lymphoblastic leukemia
genome wide
copy number
pregnant women
early life
dna methylation
allogeneic hematopoietic stem cell transplantation
single cell
gene expression
acute myeloid leukemia