Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism.
Weiguang SunShanshan LuanChangxing QiQingyi TongShan YanHua LiYonghui ZhangPublished in: Cell communication and signaling : CCS (2019)
Taken together, our findings identify AO as a potent bioactive inhibitor of GOT1 and a novel anti-tumour agent for PDAC therapy.