Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.
Arne HinrichsEvamaria Olga RiedelNikolai KlymiukAndreas BlutkeElisabeth KemterMatthias LänginMaik DahlhoffBarbara KeßlerMayuko KuromeValeri ZakhartchenkoEva-Maria JemillerDavid AyaresMartin BidlingmaierFlorian FlenkenthalerMartin Hrabě de AngelisGeorg Josef ArnoldBruno ReichartFröhlich ThomasEckhard WolfPublished in: Xenotransplantation (2020)
GHR-KO donor pigs can be used at an age beyond the steepest phase of their growth curve, potentially reducing the problem of xeno-organ overgrowth in preclinical studies.