Hypomethylation and overexpression of Th17-associated genes is a hallmark of intestinal CD4+ lymphocytes in Crohn's disease.

Zhifu SunManuel B Braga NetoYuning XiongAdytia V BhagwateHunter GibbonsMary SagstetterFeda H HamdanSaurabh BahetiJessica FritonAsha NairZhenqing YeWilliam A Faubion

Published in: Journal of Crohn's & colitis (2023)

The methylome of CD patients demonstrate an overall dominant hypermethylation yet hypomethylation is more concentrated in proinflammatory pathways, including Th17 differentiation. Hypomethylation of Th17-related genes associated with areas of open chromatin and CTCF binding sites constitutes a hallmark of CD-associated intestinal CD4 + cells.

Keyphrases

nk cells
end stage renal disease
induced apoptosis
genome wide
ejection fraction
newly diagnosed
minimally invasive
dna damage
chronic kidney disease
transcription factor
cell death
prognostic factors
peripheral blood
endoplasmic reticulum stress
signaling pathway
peritoneal dialysis
genome wide identification