Early Circulating Tumor DNA Shedding Kinetics for Prediction of Platinum Sensitivity in Patients With Small Cell Lung Cancer.
Yonina R Murciano-GoroffAngela B-Y HuiJose de Arimateia Batista Araujo-FilhoEmily G HamiltonJacob J ChabonEverett J ModingRene F BonillaEmily S LebowDaniel GomezAndreas RimnerMichelle S GinsbergMichael D OffinRitika KundraViola AllajLarry NortonJorge S Reis-FilhoPedram RazaviAlexander E DrilonDavid R JonesJames M IsbellW Victoria LaiCharles M RudinAsh A AlizadehBob T LiMaximillian DiehnPublished in: JCO precision oncology (2024)
A >2-fold decrease in ctDNA concentration was observed by C2D1 in all patients who were sensitive to platinum-based therapy and was associated with longer PFS and OS.