Thymol Protects against 5-Fluorouracil-Induced Hepatotoxicity via the Regulation of the Akt/GSK-3β Pathway in In Vivo and In Silico Experimental Models.

Yasmen F Mahran Amira M Badr Layla A AlkharashiHanaa N AlajamiNouf T AldamryNervana Moustafa BayoumyElshaymaa I ElmongySahar Soliman

Published in: Pharmaceuticals (Basel, Switzerland) (2024)

Our research is the first to shed light on thymol's potential protective effect against 5-FU- induced hepatotoxicity by inhibiting oxidative and apoptotic pathways and modulating the Akt/ GSK-3β as well as p44/42 MAPK (ERK1/2) signaling pathways.

Keyphrases

signaling pathway
pi k akt
drug induced
induced apoptosis
epithelial mesenchymal transition
high glucose
diabetic rats
cell proliferation
cell death
oxidative stress
climate change