Simultaneous editing of GABA and GSH with Hadamard-encoded MR spectroscopic imaging.

Kimberly L Chan Georg Oeltzschner Muhammad G SalehRichard A E EddenPeter B Barker

Published in: Magnetic resonance in medicine (2019)

HERMES-MRSI of GABA+ and GSH was found to be practical in the human brain with minimal measurement bias and comparable variability to separate MEGA-edited acquisitions of each metabolite performed in double the scan time. The HERMES-MRSI is a promising method for simultaneously mapping the distribution of multiple low-concentration metabolites.

Keyphrases

crispr cas
high resolution
fluorescent probe
molecular docking
computed tomography
ms ms
magnetic resonance
mass spectrometry
magnetic resonance imaging
molecular dynamics simulations