A p75 neurotrophin receptor-sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia.
Laura LatiniDaniel Souza Monteiro De AraujoRosario AmatoAlessio CanovaiLucia BuccarelloFrancesco De LoguElena NovelliAnastasiia VlasiukFrancesca MalerbaIvan ArisiRita FlorioHiroki AsariSimona CapsoniEnrica StrettoiGino VillettiBruno Pietro ImbimboMassimo Dal MonteRomina NassiniPierangelo GeppettiSilvia MarinelliAntonino CattaneoPublished in: British journal of pharmacology (2024)
Our data point to microglia as a new cell target through which NGF-induced TrkA signalling exerts neuroprotection of the RGC, emphasizing hNGFp as a powerful treatment to tackle retinal degeneration.
Keyphrases
- growth factor
- inflammatory response
- neuropathic pain
- single cell
- high glucose
- diabetic rats
- cell therapy
- electronic health record
- brain injury
- big data
- stem cells
- spinal cord injury
- robot assisted
- spinal cord
- machine learning
- oxidative stress
- binding protein
- mesenchymal stem cells
- peripheral nerve
- bone marrow
- endothelial cells
- replacement therapy