Manipulating Charge Distribution of Graphitic Carbon Nitride for Boosting NIR-II Light-Activated Reactive Oxygen Species Generation.
Mingming ShuKaidong ShenJunjun WangSen WangXiaojiao ZhuChang XuXianshun SunSen JinHongping ZhouPublished in: ACS applied bio materials (2024)
Structure engineering is of great importance to enhance the carrier separation efficiency of multiphoton absorption (MPA) materials for near-infrared (NIR) light-driven reactive oxygen species (ROS) generation. In this study, the MPA-responsive potassium/cyano group-functionalized graphitic carbon nitride was investigated, demonstrating charge redistribution and improved carrier separation efficiency by density functional theory calculations and experimental results. With various types of boosted ROS generation under UV-vis or NIR-II light irradiation, the potassium/cyano group-functionalized graphitic carbon nitride could achieve efficient multiphoton photodynamic therapy after reducing the particle size. This study developed a simple strategy to manipulate charge distribution for booting NIR light-activated ROS generation in efficient multiphoton photodynamic therapy.
Keyphrases
- photodynamic therapy
- reactive oxygen species
- density functional theory
- fluorescence imaging
- quantum dots
- visible light
- cell death
- molecular dynamics
- dna damage
- fluorescent probe
- gold nanoparticles
- radiation therapy
- reduced graphene oxide
- molecular dynamics simulations
- molecularly imprinted
- drug delivery
- cancer therapy
- high resolution
- single molecule