Reaction of H2 with mitochondria-relevant metabolites using a multifunctional molecular catalyst.
Shota YoshiokaSota NimuraMasayuki NarutoSusumu SaitoPublished in: Science advances (2020)
The Krebs cycle is the fuel/energy source for cellular activity and therefore of paramount importance for oxygen-based life. The cycle occurs in the mitochondrial matrix, where it produces and transfers electrons to generate energy-rich NADH and FADH2, as well as C4-, C5-, and C6-polycarboxylic acids as energy-poor metabolites. These metabolites are biorenewable resources that represent potential sustainable carbon feedstocks, provided that carbon-hydrogen bonds are restored to these molecules. In the present study, these polycarboxylic acids and other mitochondria-relevant metabolites underwent dehydration (alcohol-to-olefin and/or dehydrative cyclization) and reduction (hydrogenation and hydrogenolysis) to diols or triols upon reaction with H2, catalyzed by sterically confined iridium-bipyridyl complexes. The investigation of these single-metal site catalysts provides valuable molecular insights into the development of molecular technologies for the reduction and dehydration of highly functionalized carbon resources.
Keyphrases
- ms ms
- room temperature
- cell death
- highly efficient
- single molecule
- oxidative stress
- metal organic framework
- drug delivery
- endoplasmic reticulum
- quantum dots
- risk assessment
- mass spectrometry
- human health
- molecularly imprinted
- reduced graphene oxide
- visible light
- simultaneous determination
- liquid chromatography
- solid phase extraction