Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis.

Simone SerioChristina PagiatakisElettra MusolinoArianna Felicetta Pierluigi Carullo Javier Laura Francés Laura Papa Giacomo RozziNicolò SalvaraniMichele Miragoli Rosalba Gornati Giovanni Bernardini Gianluigi Condorelli Roberto Papait

Published in: Circulation research (2023)

Taken together, our results suggest how epigenetic dysregulation of glycolysis pathway enhancers could potentially be targeted to treat heart failure in the elderly.

Keyphrases

heart failure
left ventricular
high glucose
dna methylation
diabetic rats
gene expression
middle aged
cancer therapy
drug induced
atrial fibrillation
community dwelling
oxidative stress