Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma.
Varina L BoerwinkleStephen T FoldesSalvatore J TorrisiHamy TemkitWilliam D GaillardJohn F KerriganVirendra R DesaiJeffrey S RaskinAditya VedantamRanda JarrarKorwyn WilliamsSandi LamManish RanjanJanna S BrodersonDavid AdelsonAngus A WilfongDaniel J CurryPublished in: Epilepsia (2018)
For the first time, surgical SLA targeting of subcentimeter-sized EZs, located by rs-fMRI, guided surgery for intractable epilepsy. Our outcomes demonstrated the highest seizure freedom rate without surgical complications and are a significant improvement over prior reports. The approach improved freedom from seizures by 45% compared to conventional ablation, regardless of hamartoma size or anatomical classification. This technique showed the same or reduced morbidity (0%) compared to recent non-rs-fMRI-guided SLA studies with as high as 20% permanent significant morbidity.
Keyphrases
- resting state
- functional connectivity
- minimally invasive
- magnetic resonance imaging
- coronary artery bypass
- temporal lobe epilepsy
- machine learning
- surgical site infection
- deep learning
- computed tomography
- cancer therapy
- coronary artery disease
- adipose tissue
- skeletal muscle
- emergency department
- glycemic control
- insulin resistance
- diffusion weighted imaging