Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2.
Hyundong YoonLogan S DeanBoonyanudh JiyaromVedbar S KhadkaYouping DengVivek R NerurkarDominic C ChowCecilia M ShikumaGehan DevendraYoungil KohJuwon ParkPublished in: bioRxiv : the preprint server for biology (2023)
This study offers valuable insights into the immune response and cellular landscape in PPASC. The presence of elevated MLC levels and their corresponding gene signatures associated with fibrosis, immune response suppression, and altered metabolic states suggests their potential role as a driver of PPASC.
Keyphrases
- single cell
- immune response
- sars cov
- rna seq
- dendritic cells
- induced apoptosis
- genome wide
- high throughput
- cell cycle arrest
- pulmonary hypertension
- toll like receptor
- respiratory failure
- bone marrow
- acute myeloid leukemia
- respiratory syndrome coronavirus
- oxidative stress
- gene expression
- drug induced
- cell death
- dna methylation
- genome wide identification
- transcription factor
- hepatitis b virus