Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model.

José Luis Rodríguez-Ochoa Patricia Pérez-PalaciosVicente Merino-BohórquezMiriam Ortiz-PadillaAna Velázquez-EscuderoJesús Rodríguez-Baño José Manuel Rodríguez-Martínez Alvaro Pascual Fernando Docobo-Pérez

Published in: The Journal of antimicrobial chemotherapy (2024)

These data suggest that an optimized pharmacokinetic regimen may be of clinical interest for the treatment of KPC-2-producing K. pneumoniae susceptible to temocillin. These data showed activity of temocillin against KPC-2-producing K. pneumoniae susceptible to temocillin; however, a dose of 2g q8h administered over 30 min may be inadequate to prevent the emergence of resistant variants.

Keyphrases

klebsiella pneumoniae
multidrug resistant
escherichia coli
electronic health record
big data
copy number
gene expression
respiratory tract
combination therapy
smoking cessation
mass spectrometry
metal organic framework
genome wide
solid phase extraction