Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs: A population-based nested case-control study.

Yumao ZhangPatrick C Souverein Helga Gardarsdottir Hendrika A van den Ham Anke-Hilse Maitland-van der Zee Anthonius de Boer

Published in: British journal of clinical pharmacology (2020)

Among patients taking DOACs the concurrent use of antiplatelet drugs or selective serotonin reuptake inhibitors was associated with increased risk of major bleeding, while pharmacokinetic interacting drugs do not increase this risk.

Keyphrases

direct oral anticoagulants
atrial fibrillation
venous thromboembolism
protein kinase
drug induced
squamous cell carcinoma
locally advanced