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In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.

Robert M KingJildaz CaroffErin T LanganAnita LeporatiAurora Rodriguez-RodriguezChristopher M RaskettSuresh GuptaAjit S PuriPeter CaravanMatthew J GounisAlexei A Bogdanov
Published in: Journal of neurointerventional surgery (2020)
In situ decellularization of a large animal model of saccular aneurysms reproduces features of unstable aneurysms, such as chronic inflammation (up to 12 weeks) and active aneurysm wall remodeling, leading to continued growth over 8 weeks.
Keyphrases
  • coronary artery
  • oxidative stress
  • abdominal aortic aneurysm
  • gestational age