In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.
Robert M KingJildaz CaroffErin T LanganAnita LeporatiAurora Rodriguez-RodriguezChristopher M RaskettSuresh GuptaAjit S PuriPeter CaravanMatthew J GounisAlexei A BogdanovPublished in: Journal of neurointerventional surgery (2020)
In situ decellularization of a large animal model of saccular aneurysms reproduces features of unstable aneurysms, such as chronic inflammation (up to 12 weeks) and active aneurysm wall remodeling, leading to continued growth over 8 weeks.