DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births.
Chaini KonwarE Magda PriceLi Qing WangSamantha L WilsonJefferson TerryWendy P RobinsonPublished in: Epigenetics & chromatin (2018)
Our results suggest that aCA-associated placentas showed altered DNAm signatures that were not observed in the absence of aCA. This DNAm profile is consistent with the activation of the innate immune response in the placenta and/or reflect increase in neutrophils as a response to inflammation.
Keyphrases
- immune response
- dna methylation
- genome wide
- nk cells
- gestational age
- liver failure
- affordable care act
- gene expression
- oxidative stress
- respiratory failure
- preterm birth
- dendritic cells
- low birth weight
- toll like receptor
- single cell
- aortic dissection
- drug induced
- copy number
- health insurance
- healthcare
- hepatitis b virus
- intensive care unit
- inflammatory response