Plasma trough concentration of imatinib and its effect on therapeutic efficacy and adverse events in Japanese patients with GIST.
Ryugo TeranishiTsuyoshi TakahashiToshirou NishidaYukinori KurokawaKiyokazu NakajimaMasahiro KohTakahiko NishigakiTakuro SaitoKazuyoshi YamamotoKotaro YamashitaKoji TanakaTomoki MakinoMasaaki MotooriTakeshi OmoriSeiichi HirotaYoshito HayashiTetsuo TakeharaHidetoshi EguchiYuichiro DokiPublished in: International journal of clinical oncology (2023)
Edema and fatigue are potentially associated with IM plasma trough concentrations of ≥ 1283 ng/mL in Japanese patients with GISTs. Further, maintaining an IM plasma trough concentration above 917 ng/mL may improve PFS.
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