The Sweet Side of HIPK2.
Alessia GarufiValerio D'OraziGiuseppa PistrittoMara CironeGabriella D'OraziPublished in: Cancers (2023)
HIPK2 is an evolutionary conserved protein kinase which modulates many molecular pathways involved in cellular functions such as apoptosis, DNA damage response, protein stability, and protein transcription. HIPK2 plays a key role in the cancer cell response to cytotoxic drugs as its deregulation impairs drug-induced cancer cell death. HIPK2 has also been involved in regulating fibrosis, angiogenesis, and neurological diseases. Recently, hyperglycemia was found to positively and/or negatively regulate HIPK2 activity, affecting not only cancer cell response to chemotherapy but also the progression of some diabetes complications. The present review will discuss how HIPK2 may be influenced by the high glucose (HG) metabolic condition and the consequences of such regulation in medical conditions.
Keyphrases
- drug induced
- cell death
- dna damage response
- liver injury
- endothelial cells
- high glucose
- type diabetes
- transcription factor
- protein kinase
- healthcare
- cell cycle arrest
- protein protein
- cardiovascular disease
- binding protein
- amino acid
- squamous cell carcinoma
- gene expression
- small molecule
- vascular endothelial growth factor
- adipose tissue
- young adults
- glycemic control
- dna damage
- radiation therapy
- skeletal muscle
- brain injury
- locally advanced
- dna methylation
- liver fibrosis
- lymph node metastasis
- childhood cancer