Relationship between common telomere length-related genetic variations, telomere length and risk of anti-tuberculosis drug-induced hepatotoxicity in Chinese Han population: As assessed for causality using the updated RUCAM.

Xinyu ChenZhuolu HaoHongqiu PanWenpei LiuLihuan LuMeiling ZhangXiaomin HeHonggang YiShao-Wen Tang

Published in: Fundamental & clinical pharmacology (2023)

This is the first study to investigate the relationship of LTL, common telomere length-related variations, and risk of ATDH. SNP rs2736098 and rs2853677 in TERT were significantly associated with LTL, and SNP rs7675998 in NAF1 may be associated with ATDH in Chinese population.

Keyphrases

drug induced
liver injury
genome wide
adverse drug
mycobacterium tuberculosis
pet ct
emergency department
hiv aids
gene expression
genetic diversity
hepatitis c virus
hiv infected