Slow Interstitial Fluid Flow Activates TGF-β Signaling and Drives Fibrotic Responses in Human Tenon Fibroblasts.
Cornelius Jakob WiedenmannCharlotte GottwaldKosovare ZeqiriJanne FrömmichenEmma BungertMoritz GläserJeanne StröbleRobert LohmüllerThomas ReinhardJan LübkeGünther SchlunckPublished in: Cells (2023)
Slow interstitial fluid flow is sufficient to induce fibrosis, could underlie the intractable nature of fibrosis following filtering glaucoma surgery and might be a target for antifibrotic therapy.