AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner.

Julia M Vlachaki WalkerJosephine L RobbAna M CruzAmrinder MalhiPaul G Weightman PotterMichael L J AshfordRory J McCrimmonKate L J EllacottCraig Beall

Published in: Diabetes, obesity & metabolism (2017)

AMPK is required to maintain basal eATP levels but is not required for A-769662-induced increases in eATP. A-769662 (>50 μM) enhanced intracellular calcium levels leading to ATP release in an AMPK and purinergic receptor independent pathway.

Keyphrases

protein kinase
skeletal muscle
high glucose
inflammatory response
drug induced
endothelial cells
stress induced