A chronic bioluminescent model of experimental visceral leishmaniasis for accelerating drug discovery.

Raquel Álvarez-VelillaMaria Del Camino Gutiérrez-CorboCarmen PunzónMaria Yolanda Pérez-PertejoRafael Balaña-FouceManuel FresnoRosa María Reguera

Published in: PLoS neglected tropical diseases (2019)

In vivo bioimaging using a red-shifted modified Leishmania infantum strain allows the appraisal of acute and chronic stage of infection, being a powerful tool for accelerating drug development against visceral leishmaniasis during both stages and helping to bridge the gap between early discovery process and subsequent drug development.

Keyphrases

drug discovery
drug induced
liver failure
respiratory failure
fluorescent probe
living cells
hepatitis b virus
mechanical ventilation
single molecule