A chronic bioluminescent model of experimental visceral leishmaniasis for accelerating drug discovery.
Raquel Álvarez-VelillaMaria Del Camino Gutiérrez-CorboCarmen PunzónMaria Yolanda Pérez-PertejoRafael Balaña-FouceManuel FresnoRosa María RegueraPublished in: PLoS neglected tropical diseases (2019)
In vivo bioimaging using a red-shifted modified Leishmania infantum strain allows the appraisal of acute and chronic stage of infection, being a powerful tool for accelerating drug development against visceral leishmaniasis during both stages and helping to bridge the gap between early discovery process and subsequent drug development.