Effect of MEF2A and SLC22A3-LPAL2-LPA gene polymorphisms on warfarin sensitivity and responsiveness in Jordanian cardiovascular patients.

Laith Naser Al-EitanAyah Y AlmasriAdan H AlnaamnehAhmad Mihyar

Published in: PloS one (2023)

Our data refer to a lack of correlation between the MEF2A polymorphism and the efficacy of warfarin treatment in both phases of treatment, the initiation, and maintenance phases. However, only rs10455872 SNP was associated with sensitivity to warfarin during the initiation phase. Furthermore, rs3125050 has been found to be associated with the international normalized number treatment outcomes in the maintenance phase.

Keyphrases

atrial fibrillation
venous thromboembolism
end stage renal disease
direct oral anticoagulants
chronic kidney disease
ejection fraction
gene expression
genome wide
dna methylation
peritoneal dialysis
combination therapy
deep learning
patient reported