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Evaluation of a point-of-care multiplex immunochromatographic assay for the diagnosis of typhoid: results from a retrospective diagnostic accuracy study.

Rumina HasanZahida AzizullahHina ShamsSabine DittrichJason R AndrewsRichelle C CharlesJavan EsfandiariDhammika GunasekeraKevin K A TettehJyotshna Sapkota
Published in: Journal of clinical microbiology (2024)
Currently available diagnostic tests for typhoid have several limitations, including low sensitivity and specificity. Dual Path Platform Typhoid assay is a multiplex rapid test that detects IgA antibodies to lipopolysaccharide and hemolysin E antigen. It is considered to have high sensitivity and specificity, and its results were found to be highly correlated with ELISA results. However, very few studies have been conducted to evaluate this test and limited information about the accuracy of this test is present. Hence, this study evaluated the new typhoid test.
Keyphrases
  • high throughput
  • inflammatory response
  • toll like receptor
  • lps induced